Steatosis Scoring and Quantification in a Mouse Model of MASH

Study Design

Male mice were fed control or Gubra -Amylin NASH (GAN) diet for at least 40 and up to 53 weeks, with liver collected at study termination. All animals were evaluated by an ACVP board-certified veterinary pathologist according to the NAFLD Activity Scoring Scheme and then stratified by NAS score. Quantified steatosis and fibrosis endpoints were correlated to the NAS score. The in vivo portion of the study was performed by BioModels, LLC.

‍