About Us

Founded in 2021 by former colleagues, our company brings extensive non-clinical and discovery experience in model development, target identification/characterization, and efficacy programs. We are driven by an integrated team of scientists and pathologists dedicated to providing collaborative solutions tailored to the needs of pharmaceutical and biotech companies. Our main lab is headquartered in Dallas, TX, with a satellite branch in Boston, MA, allowing us to extend our reach and better serve our clients.

Meet the Founders

Alex Van Engelenburg
Alex Van Engelenburg
CEO & President
Carolyn Cook, MBA
Carolyn Cook, MBA
CFO
Jessica Durrant, MS DVM ACVP
Jessica Durrant, MS DVM ACVP
Director of Pathology
Kristin Panwell
Kristin Panwell
Director of Digital Pathology

Our Team

Our team is a dynamic and collaborative group of individuals driven by a shared passion for excellence and innovation. Together, we form a cohesive unit that is not only highly skilled but also deeply committed to achieving our common goals.
Charmaine Betancourt
Charmaine Betancourt
Histology Manager
Cecilia Cabrera
Cecilia Cabrera
Histotechnologist
Jordan Dickerson
Jordan Dickerson
Research Assistant I
Karah Panwell
Karah Panwell
IA Analyst I
Kirstie Stevens
Kirstie Stevens
Tech Lead
Taylor Branyan, PhD
Taylor Branyan, PhD
IHC Lab Manager
Joseph Krueger PhD
Joseph Krueger PhD
Business Development
Paul Murray
Paul Murray
Boston Site Lead

Our Services

01

Consultations

Planning a new study? Evaluating the performance of a new animal model? Wondering if your model translates to the human disease? Meet with our team of subject matter experts to help answer these critical questions.
02

Advanced Staining

Gain deeper insights with our IHC/ISH staining services, providing critical support for assessing efficacy and model development endpoints.
03

Pathology

Experienced pathologists support your preclinical program with a thorough microscopic evaluation, precise data interpretation, and detailed reporting to drive your research forward.
04

Histology

We offer a comprehensive range of staining options to produce high-quality slides, ensuring precise and reliable interpretation for your research needs.
05

Digital Pathology

Leverage our digital pathology services for tailored solutions, including custom algorithms and high-throughput screening with advanced image analysis.
06

Imaging

You'll have access to your bright field or fluorescent images on our web-based hosting platform. Take snapshots, compare images, or share with colleagues.

Ready to chat?

Schedule a call with our team of scientists and your designated pathologist to get started!
Contact Us

Research Areas

Evaluations and analyses tailored to answer the questions most important to your study. As a full-service lab, we help you design a custom set of endpoints integrating qualitative and quantitative methods.
Fibrosis
Cell / Gene Therapy
Colitis
Inflammation /Immunology
Cardiovascular Disease
Metabolic Disease
Oncology
Safety
Translational Research
Model Development

Fibrosis

Colonic Fibrosis / Fibrostenosis
  • Mural vs Mucosal Collagen Quantification
  • Regional Inflammation Scoring/Quantification
  • Colitis Scoring (Gland Injury, Erosion, Hyperplasia, Inflammation)
  • Epithelial Proliferation Quantification
  • Pro-Fibrotic, Pro-Inflammatory Protein/RNA Quantification
Dermal Fibrosis
  • Epidermal Hyperplasia Morphometrics
  • Dermal Fibrosis Quantification
  • Myofibroblast+Vascular Quantification
  • Inflammation Scoring/Quantification
  • Pro-Fibrotic, Pro-Inflammatory Protein/RNA Quantification
Hepatic Fibrosis
  • Collagen + Myofibroblast Quantification
  • Proliferation Quantification
  • Inflammation Scoring/Quantification
  • Pro-Fibrotic, Pro-Inflammatory Protein/RNA Quantification
  • Hepatocyte Necrosis
  • Bile Duct Hyperplasia
Idiopathic Pulmonary Fibrosis
  • Modified Ashcroft Scoring
  • Collagen Quantification
  • Inflammation Scoring/Quantification
  • Pro-Fibrotic, Pro-Inflammatory Protein/RNA Quantification
Renal Fibrosis
  • Collagen + Myofibroblast Quantification
  • Inflammation Scoring/Quantification
  • Tubular Injury Scoring or Quantification (KIM1)
  • Pro-Fibrotic, Pro-Inflammatory Protein/RNA Quantification
Systemic Sclerosis/Scleroderma
  • *Assessed by organ submitted
  • Collagen Quantification
  • Pro-Fibrotic, Pro-Inflammatory Protein/RNA Quantification
  • Myofibroblast+Vascular Quantification

Cell / Gene Therapy

Cell / Gene Therapy
  • Efficacy Analysis
  • Biodistribution (Protein/RNA Scoring/Quantification)
  • Safety Evaluation

Colitis

General Assessments
  • Inflammation Scoring/Quantification
  • Gland Injury
  • Erosion
  • Hyperplasia/Epithelial Proliferation Quantification
  • Crypt/Villus Morphometrics
  • Goblet Cell Quantification
Inflammation
  • Regional Inflammation Scoring/Quantification
  • Regional Quantification of Discrete Inflammatory Cell Populations
Fibrostenosis
  • Collagen + Myofibroblast Quantification
  • Proliferation Quantification
  • Inflammation Scoring/Quantification
  • Pro-Fibrotic, Pro-Inflammatory Protein/RNA Quantification
  • Hepatocyte Necrosis
  • Bile Duct Hyperplasia
Carcinogenesis
  • Polyp Morphometrics
  • Oncogene/Transcription Factor/Proliferation Protein/RNA Quantification

Inflammation / Immunology

Acute Lung Injury
  • American Thoracic Society ALI Scoring
  • Inflammation Scoring/Quantification
  • Pro-Inflammatory Protein/RNA Quantification
Acute Hepatitis
  • Hepatocyte Necrosis/Apoptosis Scoring/Quantification
  • Inflammation Scoring/Quantification
  • Proliferation Quantification
Arthritis
  • OARSI Scoring
  • Inflammation Scoring/Quantification
  • Pannus Scoring
  • Cartilage Damage Scoring/Morphometrics
  • Bone Resorption Scoring
  • Osteoclast Quantification
  • Pro-inflammatory, Arthrogenic Protein/RNA Quantification
Asthma
  • Inflammation Scoring/Quantification
  • Regional Quantification of Discrete Inflammatory Cell Populations(Eosinophils, Mast Cells, Lymphocytes)
  • Goblet Cell Hyperplasia Score/Quantification
  • Epithelial Cell Degeneration Score
  • Collagen Quantification
Atopic Dermatitis
  • Epidermal Hyperplasia Morphometrics
  • Epidermal Necrosis Scoring
  • Dermal Edema/Fibrosis Quantification
  • Inflammation Scoring/Quantification
  • Pro-Fibrotic, Pro-Inflammatory Protein/RNA Quantification
System Lupus Erythematosus
  • Glomerulonephritis Scoring/Morphometry
  • Inflammation Scoring/Quantification
  • Complement, Immunoglobulin Scoring/Quantification
  • Vasculitis Scoring
  • Tubular Injury Scoring
  • Lymphoid Population Quantification
  • *Assessed by organ submitted
Celiac
  • Inflammation Scoring/Quantification
  • Intra-Epithelial Lymphocyte Quantification
  • Crypt/Villus Morphometrics
  • Crypt Injury/Necrosis
Graft vs Host Disease
  • Inflammation Scoring/Quantification
  • Intra-Epithelial Lymphocyte Quantification
  • Epithelial Morphometrics
  • Necrosis/Apoptosis Scoring/Quantification
  • Collagen Quantification
  • *Assessed by organ submitted
Multiple Sclerosis (EAE)
  • Inflammation Scoring/Quantification
  • Demyelination Scoring/Quantification
  • Gliosis Quantification

Cardiovascular Disease

Pulmonary Hypertension
  • Vascular Wall Thickness Morphometrics
  • Arteriole Muscularization and Obstruction Classification
  • Arterialization (Type II PH)
  • Pulmonary Inflammation Scoring/Quantification
  • Vasculitis Scoring
  • Ashcroft Scoring (Type III PH)
  • Cardiac Inflammation/Collagen Scoring/Quantification
Atherosclerosis
  • Plaque Area/Luminal Occlusion Morphometrics
  • Plaque Classification AHA
  • Inflammation Scoring/Quantification
  • Intraplaque Vessel Scoring/Quantification
  • Thrombosis/Recanalization Scoring
Cardiomyopathy
  • Cardiomyocyte Degeneration/Necrosis Score
  • Cardiomyocyte Morphometrics
  • Inflammation Scoring/Quantification
  • Collagen Quantification
  • Microvascular Density Quantification
Myocardial Infarction
  • Infarct Area Morphometrics
  • Collagen Quantification
  • Microvascular Density Quantification
  • Inflammation Scoring/Quantification

Metabolic Disease

MASH/MASLD
  • Steatosis Quantification
  • Lipid Composition Quantification
  • NAS Scoring
  • Regional Fibrosis Quantification
  • Inflammation Quantification
Alcoholic Liver Disease
  • Steatosis Scoring/Quantification
  • Inflammation Scoring/Quantification
  • Hepatocyte Necrosis Scoring/Quantification
Storage Diseases
  • Inclusion/Accumulation Quantification
  • Inflammation Scoring/Quantification
  • Necrosis/Apoptosis Scoring/Quantification

Oncology

Oncological Endpoints
  • Descriptive Pathology (Differentiation and Morphology)
  • Regional Inflammation Quantification
  • Necrosis/apoptosis Quantification
  • Proliferation Quantification
  • Microvascular Density Quantification
  • Tumorigenesis Protein/RNA Quantification
  • H-scoring
  • Metastasis Evaluation

Safety

Safety
  • Toxicologic Pathology Evaluation by ACVP-board certified veterinary pathologists
  • Integration of in vivo, clinical pathology, and macroscopic findings with microscopic findings
  • Evaluation/Quantification of supporting histochemical stains, protein, or RNA

Translational Research

Translational Research
  • MD Pathology Evaluation of Research/Non-Clinical Human Tissue
  • Inflammation Scoring/Quantification
  • Assessment of model translation to human disease
  • Integration of human-animal comparative pathology

Model Development

Model Development
  • Support for the development of animal models of human disease
  • Team of scientists and pathologists support model development
  • Guidance in model selection based on desired clinical and microscopic features
  • Analytical endpoint selection for assessing model success
  • Development of necessary supporting assays including immunohistochemistry or in situ hybridization, and quantification